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Updated: Apr 20, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
Published on: April 27, 2014
Bladder pain syndrome/interstitial cystitis as a functional somatic syndrome
1Department of Medicine, University of Maryland School of Medicine, 10 South Pine Street, #900, Baltimore, MD 21201, United States; Department of Epidemiology and Public Health, University of Maryland School of Medicine, United States.
Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC) shares many characteristics with functional somatic syndromes (FSS). This suggests BPS/IC may be understood as an FSS in some patients, potentially improving understanding and treatment.
Area of Science:
- Urology
- Psychosomatic Medicine
- Internal Medicine
Background:
- Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC) is a chronic condition with poorly understood etiology.
- Functional Somatic Syndromes (FSS) are characterized by physical symptoms not fully explained by a general medical condition.
Purpose of the Study:
- To investigate if Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC) exhibits characteristics of a functional somatic syndrome (FSS).
Main Methods:
- A literature review was conducted to identify common FSS characteristics.
- Reports on BPS/IC were analyzed to determine the presence of these FSS characteristics.
Main Results:
- BPS/IC patients displayed nearly all identified FSS characteristics.
- Exceptions included normal light microscopy and laboratory tests, though some BPS/IC patients showed Hunner's lesions or hematuria.
Conclusions:
- The findings support the hypothesis that BPS/IC may be understood as an FSS in a subset of patients.
- This perspective may enhance understanding of BPS/IC pathogenesis and inform therapeutic strategies.
- Patients with FSS may be at risk for BPS/IC, suggesting potential preventive approaches.
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