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Updated: Apr 19, 2026

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

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Waveform-Sampling Electronics for a Whole-Body Time-of-Flight PET Scanner.

W J Ashmanskas¹, B C LeGeyt¹, F M Newcomer²

¹Department of Radiology, Physics & Instrumentation Group, University of Pennsylvania, Philadelphia, PA 19104-4209, USA.

IEEE Transactions on Nuclear Science

|December 9, 2014

Summary

This summary is machine-generated.

Waveform sampling digitally processes signals from photomultiplier tubes (PMTs) for improved precision. This technique enhances timing and energy resolution in positron emission tomography (PET) scanners.

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Area of Science:

Medical Imaging
Instrumentation
Signal Processing

Background:

Precision time and pulse-height measurements are crucial for advanced scientific instruments.
Photomultiplier tube (PMT) signal analysis traditionally faces challenges with systematic waveform variations.
Digital signal processing offers potential for enhanced measurement accuracy.

Purpose of the Study:

To investigate the application of waveform sampling for high-precision measurements in PET scanners.
To demonstrate the benefits of digital processing of PMT waveforms.
To evaluate the performance of waveform sampling on a prototype whole-body PET scanner.

Main Methods:

Implementing waveform sampling at gigasample-per-second rates for each PMT.
Utilizing digital signal processing to analyze sampled PMT waveforms.
Integrating the waveform sampling system onto the LaPET prototype scanner.

Main Results:

Waveform sampling enables straightforward digital optimization of timing and amplitude resolution.
The technique addresses systematic variations like calibration and pile-up effects.
Preliminary implementation on the LaPET prototype demonstrates feasibility.

Conclusions:

Waveform sampling is a promising technique for enhancing precision in PET scanners.
Digital processing of PMT signals via waveform sampling improves resolution and mitigates systematic errors.
The LaPET prototype serves as a valuable platform for advancing this technology.