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Increased IL-22 level in allergic rhinitis significantly correlates with clinical severity
1Department of Otolaryngology, The First People's Hospital of Foshan City, Foshan, China.
American Journal of Rhinology & Allergy
|December 17, 2014
Summary
Interleukin-22 (IL-22) and Interleukin-17A (IL-17A) are elevated in allergic rhinitis (AR) patients, correlating with symptom severity. These cytokines may drive Th2-skewed inflammation in AR.
Area of Science:
- Immunology
- Allergy Research
- Cytokine Signaling
Background:
- Interleukin-22 (IL-22) is implicated in various biological processes, but its role in allergic rhinitis (AR) pathogenesis is unclear.
- Understanding IL-22 and IL-17A involvement is crucial for AR management.
Purpose of the Study:
- To investigate IL-22 and IL-17A levels in AR patients.
- To assess the association between these cytokines and AR clinical severity.
Main Methods:
- Flow cytometry was used to quantify T helper (Th) cell frequencies (IL-22+, IL-17A+, IL-9+) in 36 AR patients and 22 controls.
- Serum IL-22 and IL-17A levels were measured via ELISA.
- Correlation with clinical AR symptoms and specific IgE levels was analyzed.
Main Results:
- AR patients showed significantly higher frequencies of IL-22+ and IL-17A+ Th cells compared to controls.
- Elevated IL-22 and IL-17A serum levels were observed in AR patients.
- Th cell frequencies and serum cytokine levels correlated with AR symptom severity (visual analog scale) and specific IgE levels.
Conclusions:
- IL-22 and IL-17A play a significant role in Th2-skewed inflammation characteristic of AR.
- These findings highlight potential therapeutic targets for allergic rhinitis.
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