Extranodal large B-cell type aggressive non-Hodgkin's lymphoma

Area of Science:

• Oncology
• Hematology
• Oral Pathology

Background:

• Non-Hodgkin's lymphoma (NHL) comprises 80-90% of all lymphomas, originating from the lymphoreticular system.
• While typically systemic, NHL can manifest with primary intraoral lesions, which are relatively uncommon but significant.
• Intraoral manifestations can serve as a presenting symptom for NHL, necessitating awareness among clinicians.

Observation:

• A 72-year-old Indian male presented with a 1.5-month history of asymptomatic left facial swelling.
• The clinical presentation prompted further investigation into potential underlying pathologies.

Findings:

• The case highlights the importance of considering NHL in the differential diagnosis of unexplained facial swellings.
• Comprehensive diagnostic workup, including clinical evaluation, radiology, histopathology, and immunohistochemistry, is essential.

Implications:

• Early identification of intraoral NHL is critical for timely intervention and management.
• Recognizing intraoral signs can lead to earlier diagnosis and potentially better treatment outcomes for patients with NHL.