Related Experiment Video
Updated: Apr 18, 2026

08:19
Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
Published on: June 1, 2012
15.2K
Force-Sensing Microneedle for Assisted Retinal Vein Cannulation*
Berk Gonenc1, Peter Gehlbach2, James Handa2
1CISST ERC at Johns Hopkins University, Baltimore, MD 21218 USA.
Summary
This study introduces a novel force-sensing instrument for retinal vein cannulation (RVC), improving visualization and safety during drug delivery. The device provides real-time feedback, enhancing precision in this challenging microsurgical procedure.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Surgical Robotics
Background:
- Retinal vein cannulation (RVC) is crucial for targeted drug delivery but faces challenges due to fragile, poorly visualized traditional cannulas.
- Current manual and robotic RVC methods are limited by the lack of real-time force feedback, increasing procedural risks.
Purpose of the Study:
- To develop and evaluate a novel force-sensing instrument for RVC.
- To enhance the safety and feasibility of both manual and robot-assisted RVC procedures through improved visualization and tactile feedback.
Main Methods:
- Development of a fiber Bragg grating-based force sensor integrated into an RVC instrument.
- Testing the instrument's ability to measure forces during retinal vein puncture in vivo.
- Implementation of an auditory feedback system triggered by force changes during vessel penetration.
Main Results:
- The force-sensing instrument successfully measured forces during retinal vein puncture with high resolution (<0.25 mN).
- A consistent, sharp drop in force was detected upon successful vessel puncture.
- This force signature was effectively translated into auditory feedback for the operator.
Conclusions:
- The developed force-sensing RVC instrument offers a significant advancement for precise drug delivery into retinal veins.
- Real-time force measurement and auditory feedback enhance procedural safety and operator guidance.
- This technology has the potential to improve outcomes in RVC procedures and related microsurgical interventions.

