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Related Concept Videos

Potentiometry: Membrane Electrodes01:15

Potentiometry: Membrane Electrodes

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Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at...
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Updated: Jul 24, 2025

Construction of a Wireless-Enabled Endoscopically Implantable Sensor for pH Monitoring with Zero-Bias Schottky Diode-based Receiver
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Ingestible pH Sensing Capsule with Thread-Based Electrochemical Sensors.

Cihan Asci1, Ruben Del-Rio-Ruiz1, Atul Sharma1

  • 1Nanolab, Advanced Technology Laboratory, Electrical and Computer Engineering, Tufts University, Medford, MA, USA 02155.

Proceedings of IEEE Sensors. IEEE International Conference on Sensors
|July 7, 2023
PubMed
Summary

A new ingestible biosensing capsule monitors intestinal pH, a key biomarker for gastrointestinal disorders. This smart device offers a less invasive diagnostic tool for conditions like inflammatory bowel disease.

Keywords:
Biosensingcapsule endoscopypH sensorsmart pillssmart threads

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Area of Science:

  • Biomedical Engineering
  • Gastroenterology
  • Sensor Technology

Background:

  • Current gastrointestinal disorder diagnostics (biopsy, endoscopy, colonoscopy) are invasive, costly, and time-consuming.
  • These methods have limited reach, especially in the small intestine.
  • pH is a crucial biomarker for various gastrointestinal conditions, including inflammatory bowel disease.

Purpose of the Study:

  • To demonstrate a novel smart ingestible biosensing capsule for monitoring intestinal pH.
  • To provide a less invasive and more accessible diagnostic alternative.

Main Methods:

  • Integration of functionalized threads as pH sensing elements.
  • Incorporation of front-end readout electronics.
  • Utilization of a 3D-printed casing for capsule construction.
  • Development of a modular sensing system design.

Main Results:

  • Successful integration of pH sensing threads with electronics and casing.
  • Demonstration of a functional ingestible biosensing capsule.
  • A modular design that simplifies fabrication and assembly.

Conclusions:

  • The developed ingestible biosensing capsule offers a promising approach for monitoring intestinal pH.
  • This technology can potentially improve the diagnosis of gastrointestinal disorders.
  • The modular design facilitates easier development and manufacturing of such devices.