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Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Chronic Pancreatitis I: Introduction01:25

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Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
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Analgesia and Pain Management01:25

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Nociception01:44

Nociception

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
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Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

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Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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Related Experiment Video

Updated: Apr 18, 2026

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
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[Chronic pain in children].

Chantal Wood, Pascale Wanquet-Thibault

    Soins. Pediatrie, Puericulture
    |January 23, 2015
    PubMed
    Summary

    Chronic pain impacts 10-20% of youth, causing physical, psychological, and social issues. Early identification and multimodal treatment are crucial for improving children's autonomy and understanding of their pain.

    Area of Science:

    • Pediatric pain management
    • Child psychology
    • Adolescent health

    Context:

    • Chronic pain affects a significant portion of children and adolescents.
    • Beyond physical symptoms, chronic pain leads to considerable psychological and social challenges.
    • These issues are frequently underestimated and overlooked in clinical practice.

    Purpose:

    • To increase awareness among healthcare professionals regarding pediatric chronic pain.
    • To facilitate early identification of young patients experiencing chronic pain.
    • To promote adapted, multimodal treatment strategies for pediatric chronic pain.

    Summary:

    • Chronic pain affects 10-20% of children and teenagers, presenting physical, psychological, and social difficulties.
    • Early recognition and intervention are vital for addressing these complex needs.

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  • The primary goal is to enhance patient autonomy and understanding of pain, treating underlying causes when possible.

    • Impact:

    • Improved identification of pediatric chronic pain patients.
    • Enhanced multimodal treatment approaches for youth with chronic pain.
    • Increased patient autonomy and better pain management outcomes for children and adolescents.