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Inertial cavitation threshold of nested microbubbles.

N Wallace¹, S Dicker¹, Peter Lewin¹

¹Department of Chemical Engineering, Drexel University, Philadelphia, PA, USA.

|January 27, 2015

Summary

This summary is machine-generated.

This study shows that nesting ultrasound contrast agent (UCA) microbubbles within a poly-lactic acid shell significantly reduces inertial cavitation events. Smaller shell diameters further decrease microbubble destruction, enhancing UCA stability.

Keywords:

Cavitation threshold Inertial cavitation Microbubble Microcapsule Ultrasound contrast agent

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Area of Science:

Biomedical Engineering
Acoustic Physics
Materials Science

Background:

Ultrasound contrast agents (UCAs) exhibit cavitation, leading to beneficial and detrimental bioeffects.
Determining the inertial cavitation threshold of UCA microbubbles is crucial for applications in contrast imaging and targeted therapies.

Purpose of the Study:

To evaluate a novel UCA formulation with a poly-lactic acid (PLA) shell.
To investigate the inertial cavitation behavior of these nested microbubbles.
To assess the impact of shell diameter and microbubble concentration on cavitation thresholds.

Main Methods:

A home-built cavitation detection system utilizing two 2.25 MHz transducers at a 90° angle was employed.
Microbubbles were exposed to controlled acoustic pressures (50 kPa to 2 MPa) using a specific pulse sequence.
The formulation consisted of SF6 microbubbles coated with DSPC PEG-3000 and nested within PLA shells of varying diameters.

Main Results:

The nesting shell dramatically reduced inertial cavitation from 97.96% to 19.09% for a 2.53 μm shell.
A decrease in shell diameter correlated with a lower percentage of inertially cavitating microbubbles.
At 1 MPa, sample destruction decreased from 51.02% (20.52 μm shell) to 5.37% (1.95 μm shell).

Conclusions:

The PLA nesting shell effectively suppresses inertial cavitation in UCAs.
Smaller shell diameters enhance UCA stability by further reducing cavitation.
This novel UCA formulation shows promise for controlled ultrasound applications.