Multifocal electroretinogram in birdshot chorioretinopathy.

Area of Science:

• Ophthalmology
• Retinal Imaging
• Electrophysiology

Background:

• Birdshot chorioretinopathy is a rare inflammatory condition affecting the choroid and retina.
• Early detection and monitoring are crucial for managing this sight-threatening disease.

Purpose of the Study:

• To characterize multifocal electroretinogram (MERG) parameters in patients diagnosed with birdshot chorioretinopathy.
• To establish correlations between MERG findings and other visual function assessments.

Main Methods:

• Prospective evaluation of MERG using the Vision Monitor system in 28 birdshot chorioretinopathy patients.
• Matching patients with 27 healthy controls based on age, axial length, and lens status.

Main Results:

• Birdshot chorioretinopathy eyes exhibited reduced amplitudes (root mean square, P1, N2) and altered implicit times (N1, P1) compared to controls.
• MERG parameter alterations showed significant correlation with visual acuity, visual field defects, foveal threshold, and color vision.
• Fluorescein angiographic scores correlated with specific MERG amplitudes and implicit times.

Conclusions:

• MERG parameters are significantly impaired in birdshot chorioretinopathy.
• MERG findings correlate well with other anatomical and functional tests, offering valuable insights.
• Periodic MERG testing can assist in guiding immunosuppressive treatment strategies.