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Test-retest reliability of diffusion measures in cerebral white matter: A multiband diffusion MRI study
Fei Duan1,2, Tengda Zhao1,2, Yong He1,2
1State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
Journal of Magnetic Resonance Imaging : JMRI
|February 6, 2015
Summary
Multiband diffusion MRI shows moderate to high test-retest reliability for cerebral white matter measures. Fractional anisotropy (FA) demonstrated the highest reproducibility, suggesting utility for individual difference studies.
Area of Science:
- Neuroimaging
- Diffusion MRI
- White Matter Analysis
Background:
- Investigating test-retest (TRT) reliability of diffusion measures in cerebral white matter.
- Utilizing diffusion MRI datasets acquired with multiband acceleration.
Purpose of the Study:
- To assess the TRT reliability of diffusion measures (FA, MD, PD, TD) using multiband accelerated diffusion MRI.
- To compare the reproducibility of different automated analysis methods.
Main Methods:
- Employed a multiband diffusion MRI dataset with two scanning sessions.
- Utilized voxel-level analyses (VBA, TBSS) and atlas ROI-based analysis.
- Assessed reproducibility using intra-class correlation coefficient (ICC).
Main Results:
- Demonstrated moderate to high reproducibility (ICC > 0.4) across analysis approaches.
- Fractional anisotropy (FA) showed the highest reproducibility (mean ICC = 0.70), while mean diffusivity (MD) showed the lowest (mean ICC = 0.55).
- Commissural tracts exhibited higher reproducibility than other tract categories; brainstem tracts showed the poorest reliability.
Conclusions:
- Multiband EPI sequences show potential utility for studying individual differences in cerebral white matter.
- Findings provide valuable reference data for future white matter research.
