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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
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Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
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Rhizaria are a diverse group of unicellular protists characterized by their threadlike cytoplasmic extensions known as pseudopodia. These structures aid in both locomotion and feeding, giving Rhizaria an amoeboid appearance. Their amoeboid morphology once led to taxonomic confusion, but molecular phylogenetics has clarified their evolutionary placement and emphasized their shared use of pseudopodia despite divergent lineages.This clade comprises diverse lineages such as Chlorarachniophyta,...
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Author Spotlight: Developing Synthetic Microbial Communities for Generating Second-Generation Biofertilizers
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[Structural diversity oriented synthesis to explore the living world].

Yung-Sing Wong1

  • 1Université Grenoble Alpes;   - CNRS, département de pharmacochimie moléculaire, UMR 5063, F-38041 Grenoble Cedex, France.

Medecine Sciences : M/S
|February 7, 2015
PubMed
Summary

Novel synthetic strategies create diverse chemical libraries rapidly. This approach expands chemical space for discovering and optimizing bioactive compounds efficiently.

Area of Science:

  • Organic Chemistry
  • Medicinal Chemistry
  • Synthetic Chemistry

Context:

  • Traditional chemical libraries have limitations in exploring tridimensional chemical space.
  • There is a need for methods to access novel molecular architectures.

Purpose:

  • To develop synthetic strategies that rapidly generate structurally diverse compound libraries.
  • To address the gap in unoccupied chemical space.

Summary:

  • Structural diversity-oriented synthesis utilizes divergent reactions to create large libraries in 2-3 steps.
  • This methodology ensures access to a high number of structurally diverse products.
  • Examples demonstrate increasing molecular complexity and diversity for drug discovery.

Impact:

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  • Facilitates the discovery and optimization of bioactive compounds.
  • Expands the accessible chemical space for drug development.
  • Enables efficient exploration of novel molecular structures.