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Related Concept Videos

Activation of Integrins01:15

Activation of Integrins

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Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
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Intracellular Signaling Affects Focal Adhesions01:17

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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
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Integrins01:10

Integrins

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Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
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Protein Translocation Machinery on the ER Membrane01:28

Protein Translocation Machinery on the ER Membrane

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The translocon complex situated on the ER membrane is the main gateway for the protein secretory pathway. It facilitates the transport of nascent peptides into the ER lumen and their insertion into the ER membrane.
Sec61 protein conducting channel
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Protein Transport into the Inner Mitochondrial Membrane01:34

Protein Transport into the Inner Mitochondrial Membrane

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Nuclear encoded mitochondrial precursors are imported to the inner membrane in a multistep process involving two separate translocons, TIM22 and TIM23. TIM23 is a cation-selective pore that remains closed by the N terminal segment of the protein. Negative charges on the TIM23 act as a receptor for the incoming precursor, pulling the positively charged matrix-targeting sequence for peptide insertion and translocation.
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GPI Anchoring of Proteins in the ER Membrane01:29

GPI Anchoring of Proteins in the ER Membrane

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GPI-anchoring is a post-translational, reversible protein modification that is ubiquitous in eukaryotes. Such proteins are primarily present on the exoplasmic leaflet of the plasma membrane.
GPI-anchor structure
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Related Experiment Video

Updated: Apr 17, 2026

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
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Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

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Integrin traffic - the update.

Nicola De Franceschi1, Hellyeh Hamidi1, Jonna Alanko1

  • 1Turku Centre for Biotechnology, University of Turku, Turku 20521, Finland.

Journal of Cell Science
|February 10, 2015
PubMed
Summary
This summary is machine-generated.

Integrin traffic, involving endocytic and exocytic pathways, is crucial for cell adhesion and signaling. This update reviews how integrin trafficking regulates cell fate and impacts diseases like cancer.

Keywords:
IntegrinInvasionMigrationRab GTPasesSignalling crosstalkTrafficking

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Integrins are key cell surface receptors mediating cell-extracellular matrix (ECM) adhesion.
  • Integrin-ligand interactions anchor cells and initiate signaling cascades.
  • Dynamic remodeling of integrin adhesions via trafficking is vital for cellular processes.

Purpose of the Study:

  • To provide an update on the field of integrin traffic.
  • To highlight the link between integrin trafficking and cell signaling.
  • To emphasize the role of endosomal pathways in integrin regulation.

Main Methods:

  • Review of current literature on integrin trafficking.
  • Analysis of endocytic and exocytic pathways involved in integrin regulation.
  • Discussion of the implications of integrin traffic in cellular processes and disease.

Main Results:

  • Integrin traffic is intimately linked with intracellular signaling.
  • Endosomal pathways are critical regulators of integrin stability and expression.
  • Dysregulated integrin traffic is implicated in pathological conditions, particularly cancer.

Conclusions:

  • Integrin trafficking is a fundamental mechanism controlling cell adhesion and signaling.
  • Understanding integrin traffic is essential for comprehending cell behavior and disease pathogenesis.
  • This review serves as an update for researchers in the field of integrin traffic.