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Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test
Published on: March 23, 2013
Gastroparesis: definitions and diagnosis
Pankaj Jay Pasricha1, Henry P Parkman2
1Johns Hopkins Center for Neurogastroenterology, Johns Hopkins School of Medicine, 720 Rutland Street, Ross 958, Baltimore, MD 21205, USA; Johns Hopkins Carey School of Business, Baltimore, MD, USA.
Abstract:
Gastroparesis is a chronic symptomatic disorder of the stomach characterized by delayed emptying without evidence of mechanical obstruction. Symptoms of gastroparesis include nausea, vomiting, early satiety, postprandial fullness, and upper abdominal pain. The 3 main causes are diabetic, postsurgical, and idiopathic. Diagnosis is confirmed by demonstrating delayed gastric emptying. Gastric emptying rates measured by gastric motor testing generally correlate poorly with symptoms and quality of life in patients with gastroparesis. It may be appropriate to reconsider the definition of gastroparesis, recognizing it as a broader spectrum of gastric neuromuscular dysfunction.
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