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Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test
Published on: March 23, 2013
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Gastroparesis: definitions and diagnosis
Pankaj Jay Pasricha1, Henry P Parkman2
1Johns Hopkins Center for Neurogastroenterology, Johns Hopkins School of Medicine, 720 Rutland Street, Ross 958, Baltimore, MD 21205, USA; Johns Hopkins Carey School of Business, Baltimore, MD, USA.
Gastroenterology Clinics of North America
|February 11, 2015
Summary
Gastroparesis, a stomach disorder causing delayed emptying, often shows poor correlation between gastric emptying rates and patient symptoms. Rethinking its definition may better capture the spectrum of gastric neuromuscular dysfunction.
Area of Science:
- Gastroenterology
- Neurology
Background:
- Gastroparesis is a chronic disorder marked by delayed gastric emptying without mechanical blockage.
- Key symptoms include nausea, vomiting, early satiety, and abdominal pain.
Purpose of the Study:
- To evaluate the correlation between gastric emptying rates and patient-reported symptoms and quality of life in gastroparesis.
- To discuss the potential need for redefining gastroparesis.
Main Methods:
- Diagnosis confirmed by delayed gastric emptying tests.
- Gastric motor testing used to measure gastric emptying rates.
Main Results:
- Gastric emptying rates measured by gastric motor testing showed poor correlation with gastroparesis symptoms and quality of life.
- Common causes include diabetes, surgery, and idiopathic factors.
Conclusions:
- The current definition of gastroparesis may be insufficient.
- Recognizing gastroparesis as a spectrum of gastric neuromuscular dysfunction is proposed.
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