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Published on: February 9, 2019
Sugar and pH dual-responsive snap-top nanocarriers based on mesoporous silica-coated Fe3O4 magnetic nanoparticles for
Xi-Long Qiu1, Qing-Lan Li, Yue Zhou
1State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China. ywyang@jlu.edu.cn.
Abstract:
A facile strategy to prepare snap-top magnetic nanocarriers has been developed where ultrasmall superparamagnetic Fe3O4 nanoparticles were used as the core with mesoporous silica as the shell followed by the covalent installation of a layer of β-cyclodextrins on the outer surfaces. The smart hybrid nanomaterials showed remarkable pH- and sugar-responsive cargo release property and low cytotoxicity as proved by an MTT assay with HEK293T cell lines.
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