Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fetal Circulation01:14

Fetal Circulation

5.0K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
5.0K
Development of the Heart01:27

Development of the Heart

4.0K
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
4.0K
Development of Blood Vessels01:07

Development of Blood Vessels

2.0K
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
2.0K
Physiology of the Heart: The Cardiac Cycle01:18

Physiology of the Heart: The Cardiac Cycle

15.3K
The cardiac cycle describes the events from one heartbeat to the next. It includes three main phases: diastole, atrial systole, and ventricular systole, all driven by changes in chamber pressures and the function of heart valves.
Diastole: The Relaxation Phase
During diastole, all four heart chambers relax. The atrioventricular (AV) valves open, and the semilunar valves close. This phase sees the lowest chamber pressures, promoting ventricular filling. Venous blood enters the heart through the...
15.3K
Cardiac Cycle01:29

Cardiac Cycle

17.2K
The cardiac cycle refers to the sequence of events that occur in the heart from the beginning of one heartbeat to the next. It's characterized by alternating periods of contraction (systole) and relaxation (diastole) of the heart muscles.
During the cardiac cycle, blood flow through the heart is regulated entirely by changing pressure gradients. This sequence of events begins with the heart in a state of total relaxation, known as mid-to-late diastole, during which blood passively flows from...
17.2K
Overview of the Cardiovascular System01:14

Overview of the Cardiovascular System

17.1K
The cardiovascular system is a vital transportation system in the body. It comprises the heart and blood vessels and facilitates the exchange of gases, nutrients, and waste products.
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
17.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

International Multicenter Video Review on Neonatal Procedures: Lessons Learned from a Collaborative Study.

Children (Basel, Switzerland)·2026
Same author

Gentle limb fixation for a faster reliable heart rate obtained with pulse oximeter at birth.

Resuscitation·2026
Same author

Repeated versus selective tactile stimulation for preterm infants at birth: protocol and statistical analysis plan for a stepped-wedge cluster randomised controlled trial (NEU-stim trial).

BMJ open·2026
Same author

Acceptability of the knee-to-chest flexion maneuver to reduce neonatal respiratory distress after elective cesarean section: a qualitative study among healthcare providers.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same author

Prevalence of methemoglobinemia after lidocaine as add-on therapy in neonatal seizures.

European journal of pediatrics·2026
Same author

Initial Resuscitation of Preterm Infants With Targeted Oxygen.

JAMA·2026
Same journal

Polycyclic aromatic hydrocarbons and perinatal outcomes: a scoping review.

Pediatric research·2026
Same journal

Interindividual variability in metformin pharmacokinetics in pediatric patients.

Pediatric research·2026
Same journal

Comparison of Crohn's disease exclusion diet and exclusive enteral nutrition in prospectively followed paediatric patients with Crohn's disease.

Pediatric research·2026
Same journal

Natural Language Processing (NLP) tools are superior to ICD-10 codes in capturing clinically relevant information.

Pediatric research·2026
Same journal

Prenatal cannabinoid and nicotine exposure: senescence as a developmental origin of bronchopulmonary dysplasia?

Pediatric research·2026
Same journal

Bob Sun: ECI Biocommentary.

Pediatric research·2026
See all related articles

Related Experiment Video

Updated: Apr 17, 2026

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse
08:19

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

Published on: December 16, 2022

2.6K

Cardiovascular transition at birth: a physiological sequence.

Stuart B Hooper1, Arjan B Te Pas2, Justin Lang3

  • 11] The Ritchie Centre, MIMR-PHI Institute of Medical Research, Monash University, Clayton, Victoria, Australia [2] Department of Obstetrics and Gynecology, Monash University, Clayton, Victoria, Australia.

Pediatric Research
|February 12, 2015
PubMed
Summary
This summary is machine-generated.

Delayed umbilical cord clamping may benefit apneic newborns. Starting ventilation before cord clamping mitigates cardiovascular risks associated with immediate clamping, prioritizing infant physiology over arbitrary time intervals for optimal outcomes.

More Related Videos

A Novel Ex Ovo Banding Technique to Alter Intracardiac Hemodynamics in an Embryonic Chicken System
08:09

A Novel Ex Ovo Banding Technique to Alter Intracardiac Hemodynamics in an Embryonic Chicken System

Published on: May 13, 2016

7.1K
En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
08:57

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

Published on: July 27, 2022

2.2K

Related Experiment Videos

Last Updated: Apr 17, 2026

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse
08:19

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

Published on: December 16, 2022

2.6K
A Novel Ex Ovo Banding Technique to Alter Intracardiac Hemodynamics in an Embryonic Chicken System
08:09

A Novel Ex Ovo Banding Technique to Alter Intracardiac Hemodynamics in an Embryonic Chicken System

Published on: May 13, 2016

7.1K
En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
08:57

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

Published on: July 27, 2022

2.2K

Area of Science:

  • Neonatal Physiology
  • Cardiovascular Adaptation
  • Perinatal Medicine

Background:

  • Birth transitions involve critical cardiovascular adjustments driven by lung aeration.
  • Increased pulmonary blood flow (PBF) is essential for gas exchange and left heart preload post-birth.
  • Umbilical cord clamping timing significantly impacts neonatal hemodynamics and cardiac output.

Purpose of the Study:

  • To evaluate the cardiovascular effects of ventilation onset relative to umbilical cord clamping.
  • To determine optimal timing strategies for cord clamping based on infant physiology.
  • To assess the impact of delayed cord clamping on apneic infants.

Main Methods:

  • Analysis of cardiovascular changes triggered by lung aeration and cord clamping.
  • Comparison of immediate versus delayed cord clamping scenarios.
  • Investigation of ventilation onset timing in relation to cord clamping.

Main Results:

  • Delayed PBF increase due to early cord clamping reduces left heart preload and cardiac output.
  • Delayed ventilation onset post-cord clamping increases risk of ischemic insult.
  • Ventilation onset before cord clamping mitigates adverse cardiovascular effects of immediate clamping.

Conclusions:

  • Umbilical cord clamping timing should be guided by infant physiology, not arbitrary durations.
  • Prioritizing ventilation onset before cord clamping can prevent cardiovascular compromise.
  • Delayed cord clamping may offer the greatest benefit to apneic newborns requiring resuscitation.