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Updated: Apr 17, 2026
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Determining Cell Number During Cell Culture using the Scepter Cell Counter
Published on: November 26, 2010
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Development, history, and future of automated cell counters
Ralph Green1, Sebastian Wachsmann-Hogiu2
1Department of Pathology and Laboratory Medicine, UC Davis Medical Diagnostics, University of California, Davis Health System, 4400 V Street, PATH Building, Sacramento, CA 95817, USA.
Clinics in Laboratory Medicine
|February 14, 2015
Summary
Modern hematology instruments use optical or impedance methods for accurate blood cell analysis. Future advancements aim for new parameters, point-of-care testing, and in-vivo measurements.
Area of Science:
- Hematology
- Medical Instrumentation
- Biomedical Engineering
Background:
- Automated hematology instruments are crucial for blood cell analysis.
- Current technologies include optical (light scatter) and impedance-based (Coulter principle) methods.
Observation:
- These instruments provide accurate, precise, and rapid enumeration and evaluation of blood cells.
- The cost-effectiveness of these methods has significantly improved.
Findings:
- Hematology instrumentation combines optical and impedance techniques for comprehensive analysis.
- Continuous improvements enhance the speed and accuracy of blood cell counting.
Implications:
- Future developments focus on incorporating novel parameters into automated analyzers.
- Point-of-care instrumentation and in-vivo analysis promise noninvasive, continuous blood monitoring.
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