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Updated: Apr 17, 2026

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
Endocrine and reproductive effects of polycystic ovarian syndrome
Laura C Ecklund1, Rebecca S Usadi2
1Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28203, USA.
Abstract:
Management strategies for overweight and obese women with polycystic ovarian syndrome (PCOS) who desire fertility should include weight loss. Even a small reduction in body weight can improve ovulatory function and pregnancy rate and reduce adverse obstetric outcomes. New data suggest that letrozole should be considered as the new first-line medical treatment of anovulatory infertility in PCOS over clomiphene citrate. Second-line treatments for anovulatory infertility include in vitro fertilization, gonadotropins, or ovarian drilling.
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