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Natural grape extracts regulate colon cancer cells malignancy.
Paola Signorelli1, Carlotta Fabiani, Andrea Brizzolari
1a Department of Health Sciences , University of Milan , Milan , Italy , and San Paolo Hospital , Milan , Italy.
Nutrition and Cancer
|February 24, 2015
Summary
Liofenol™, a natural red wine extract, inhibits colon cancer cell proliferation by activating antioxidant responses and modulating cell cycle regulators. This grape extract promotes cell differentiation and reduces cancer cell migration.
Area of Science:
- Oncology
- Molecular Biology
- Nutritional Science
Background:
- Natural dietary compounds can regulate inflammation and cancer progression.
- Grape-derived molecules, particularly polyphenols, are known for their health benefits.
- Liofenol™ is a natural, alcohol-free red wine extract rich in diverse bioactive components.
Purpose of the Study:
- To investigate the anti-cancer properties of Liofenol™ on colon cancer cells.
- To elucidate the molecular mechanisms underlying Liofenol™'s effects.
- To assess Liofenol™'s impact on cell proliferation, cell cycle, and cancer-related pathways.
Main Methods:
- Treatment of colon cancer cell line HCT116 with Liofenol™.
- Analysis of cell proliferation, cell cycle gatekeepers (p53, p21), and sphingolipid mediators (dihydroceramides).
- Assessment of antioxidant response via Nrf2 activation and evaluation of effects on cell morphology, migration, and epithelial-mesenchymal transition markers.
Main Results:
- Liofenol™ significantly reduced HCT116 cell proliferation.
- Increased levels of p53, p21, and dihydroceramides were observed, indicating cell cycle arrest.
- Enhanced antioxidant response through Nrf2 activation and reduced cancer cell migration and stem-like characteristics were noted.
Conclusions:
- Liofenol™ activates molecular pathways, including Nrf2 signaling and sphingolipid mediators, to reduce digestive tract cancer cell proliferation.
- The extract promotes cell differentiation and inhibits processes associated with malignant transition.
- Liofenol™ demonstrates potential as a dietary intervention for cancer prevention or therapy support.
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