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Updated: Apr 17, 2026

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Neovascular age-related macular degeneration associated with no light perception
Background And Objective:
To study eyes with no light perception (NLP) occurring secondary to neovascular age-related macular degeneration (AMD).
Patients And Methods:
Records of consecutive patients with neovascular AMD seen during a 10-year period were reviewed to ascertain which patients had NLP due to neovascular AMD.
Results:
Ten of 1,150 patients (0.9%) with neovascular AMD had NLP in one eye (study eye) from neovascular AMD. All 10 patients had bilateral neovascular AMD. Each study eye had a large macular disciform scar and 360° peripapillary subretinal fibrovascular tissue. Seven of nine (78%) study eyes had optic disc pallor, versus none of eight fellow eyes (P = .04). Mean fellow eye vision was 20/231, ranging from 20/50 to NLP (P = .006 vs study eyes). No seeing fellow eye had choroidal neovascularization encircling the optic disc (P = .0004).
Conclusion:
NLP from neovascular AMD is associated with 360° peripapillary subretinal fibrosis. This fibrosis may cause chronic ischemic optic neuropathy contributing to extinguished vision.
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