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P388 leukemia in CDF₁ mice as the test system for studies of tumor-associated neoangiogenesis and hypercoagulation
A P Trashkov1, A V Panchenko, E S Kayukova
1St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russia, alexandr.trashkov@gmail.com.
Abstract:
Blood levels of vascular endothelial growth factor, the main marker of angiogenesis activity, and coagulation hemostasis were studied in CDF1 mice with transplanted P-388 lymphocytic leukemia. Blood levels of vascular endothelial growth factor increased by 168% in mice with tumors. The animals developed the hypercoagulation syndrome manifesting in shorter activated partial thromboplastin time and prothrombin time and development of hyperfibrinogenemia.
