Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.7K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.7K
Glaucoma: Overview01:25

Glaucoma: Overview

1.7K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.7K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Quality of Life in Patients with Posterior Segment Eye Diseases.

Journal of ophthalmic & vision research·2026
Same authorSame journal

Anterior Segment Eye Diseases and Quality of Life: An Updated Comprehensive Narrative Review.

Journal of ophthalmic & vision research·2026
Same author

Positive Airway Pressure and Long-Term Glaucoma Risk in Obstructive Sleep Apnea: A Cohort Study.

Ophthalmology. Glaucoma·2026
Same author

Progression in Preperimetric Glaucoma Eyes With and Without Microvasculature Dropout.

American journal of ophthalmology·2026
Same author

Structural retinal and choroidal changes in keratoconus: A cross-sectional OCT study stratified by ABCD grading.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
Same author

Association of Deep Optic Nerve Head Structural Remodeling with Choroidal Microvasculature Dropout in Glaucoma with and without Myopia.

American journal of ophthalmology·2026

Related Experiment Video

Updated: Apr 17, 2026

Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography
03:47

Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography

Published on: November 1, 2024

452

Central corneal thickness in primary angle closure and open angle glaucoma.

Sasan Moghimi1, Hamidreza Torabi2, Hesam Hashemian2

  • 1Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran ; Koret Vision Center, University of California, San Francisco Medical School, San Francisco, CA, USA.

Journal of Ophthalmic & Vision Research
|February 25, 2015
PubMed
Summary

Central corneal thickness (CCT) was thicker in primary angle closure glaucoma (PACG) eyes compared to primary open-angle glaucoma (POAG) and control eyes. Glaucoma severity inversely correlated with CCT in both PACG and POAG.

Keywords:
Central Corneal ThicknessPrimary Angle Closure GlaucomaPrimary Open-angle Glaucoma, Intraocular Pressure

More Related Videos

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.9K
Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

10.0K

Related Experiment Videos

Last Updated: Apr 17, 2026

Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography
03:47

Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography

Published on: November 1, 2024

452
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.9K
Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

10.0K

Area of Science:

  • Ophthalmology
  • Corneal Physiology
  • Glaucomatology

Background:

  • Central corneal thickness (CCT) is a key factor in glaucoma diagnosis and management.
  • Variations in CCT may influence intraocular pressure (IOP) measurements and disease progression.
  • Understanding CCT differences between glaucoma subtypes is crucial for accurate assessment.

Purpose of the Study:

  • To quantitatively compare CCT between primary angle closure glaucoma (PACG) and primary open-angle glaucoma (POAG) patients.
  • To investigate the correlation between CCT and glaucoma severity, measured by mean deviation (MD) on visual field (VF) testing.
  • To analyze CCT in relation to age and sex in these patient groups.

Main Methods:

  • Retrospective review of patient records from a tertiary glaucoma service.
  • Ultrasound pachymetry used for CCT measurement.
  • Statistical analysis including Student's t-test, ANCOVA, and regression models to compare groups and assess correlations.

Main Results:

  • A total of 115 PACG, 215 POAG patients, and 100 controls were analyzed.
  • PACG eyes exhibited significantly thicker CCT (545.5 ± 46.1 μm) than POAG (531.7 ± 37.3 μm) and control eyes (531.0 ± 38.3 μm) after age and gender adjustment.
  • Inverse correlation found between CCT and glaucoma severity (MD of VF) in both PACG (β = 1.38, P = 0.04) and POAG (β = 1.89, P = 0.02) eyes.

Conclusions:

  • Primary angle closure glaucoma eyes demonstrate thicker central corneal thickness compared to primary open-angle glaucoma and healthy eyes in the studied Iranian population.
  • Glaucoma disease severity is inversely associated with central corneal thickness in both PACG and POAG.
  • These findings highlight the importance of considering CCT in the management of different glaucoma types.