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Snap Chip for Cross-reactivity-free and Spotter-free Multiplexed Sandwich Immunoassays

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Published on: November 13, 2017

Research highlights: aptamers on a chip.

Donghyuk Kim¹, Ivan Pushkarsky, Andy Tay

¹Department of Bioengineering, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, 420 Westwood Plaza, 5121 Engineering V, Box 951600, Los Angeles, California 90095, USA. dicarlo@ucla.edu.

|February 25, 2015

Summary

This summary is machine-generated.

Aptamers, or oligonucleotide/peptide molecules, offer stable, versatile tools for research and medicine. New methods enhance aptamer selection and create advanced sensors for broader applications.

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Area of Science:

Biochemistry and Molecular Biology
Biotechnology
Sensor Technology

Background:

Aptamers are highly specific binding molecules with applications in research and clinical settings.
Advances in sequencing and automation are improving aptamer selection processes.
Challenges remain in maximizing aptamer utility and developing novel applications.

Purpose of the Study:

To highlight recent advancements in aptamer technology.
To address challenges in the wider application of aptamers.
To showcase innovative approaches for aptamer discovery and sensor development.

Main Methods:

Array-based discovery of multivalent aptamers for enhanced binding affinity.
Development of paired aptamers targeting previously bound proteins.
Utilizing microfluidic and microarray technologies for automated aptamer selection.
Engineering refreshable sensors for long-term signal detection.

Main Results:

Demonstrated success in developing high-affinity aptamers through multivalent strategies.
Addressed challenges in analyzing local cell secretions.
Created refreshable sensors capable of hundreds of detection cycles.
Showcased potential for air-scavenged water to refresh sensors, reducing reagent needs.

Conclusions:

Aptamer technology is rapidly advancing, offering solutions for complex biological and sensing challenges.
Novel selection and engineering methods are expanding the scope of aptamer applications.
Future directions include the development of robust, reagent-minimal wearable sensors.