Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurulation01:30

Neurulation

47.7K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
47.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expression of en in the Prosencephalon Heterotopically Transplanted into the Mesencephalon: (en/prosencephalon/mesencephalon/heterotopic transplantation/tectum).

Development, growth & differentiation·2023
Same author

MOUSE MUSCLE CELL DIFFERENTIATION IN CLONAL CULTURE.

Development, growth & differentiation·2023
Same author

The Ontogeny of Thymic Myoid Cells in the Chicken: (chick/thymus/myoid cells/development/immunohistochemistry).

Development, growth & differentiation·2023
Same author

The Prosencephalon Has the Capacity to Differentiate into the Optic Tectum: Analysis by Chick-Specific Monoclonal Antibodies in Quail-Chick-Chimeric Brains: (Quail-chick-chimera/monoclonal antibody/chick specific/prosencephalon/optic tectum).

Development, growth & differentiation·2023
Same author

Effects of digit tissue on cell death and ectopic cartilage formation in the interdigital zone in chick leg buds.

Development, growth & differentiation·2023
Same author

Cross-talk between EGFR and BMP signals regulates chondrocyte maturation during endochondral ossification.

Developmental dynamics : an official publication of the American Association of Anatomists·2021
Same journal

Atypical Cadherin Fat2 is Involved in Axogenesis of Cerebellar Granule Cells in Zebrafish.

Development, growth & differentiation·2026
Same journal

Sbno1 and Usp8 Cooperate to Enhance Notch Signaling in Regulating Neural Stem Cells.

Development, growth & differentiation·2026
Same journal

Computer-Aided Sperm Analysis Protocol for Evaluating Sperm Motility in Japanese Medaka.

Development, growth & differentiation·2026
Same journal

Cooperative Roles of Pds5a and Pds5b Constrain Long-Range Chromatin Interactions in Vertebrate Embryos.

Development, growth & differentiation·2026
Same journal

Derepression of a Subset of Meiotic Proteins in Primordial Germ Cells of max Mutant Zebrafish.

Development, growth & differentiation·2026
Same journal

Convergence of Cell Biology and Developmental Biology: A Report of the Joint Meeting of the 77th JSCB and the 58th JSDB.

Development, growth & differentiation·2026
See all related articles

Related Experiment Video

Updated: Apr 16, 2026

Visualization of Tangential Cell Migration in the Developing Chick Optic Tectum
08:28

Visualization of Tangential Cell Migration in the Developing Chick Optic Tectum

Published on: October 24, 2018

7.0K

Engrailed and tectum development.

Minoru Omi1, Harukazu Nakamura

  • 1Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui, 910-1193, Japan.

Development, Growth & Differentiation
|February 27, 2015
PubMed
Summary
This summary is machine-generated.

Engrailed (En) is vital for optic tectum development in vertebrates. This gene regulates mesencephalon regionalization, rostrocaudal polarity, and cell migration during tectal laminar formation.

Keywords:
Engrailedlaminar formationoptic tectumregionalizationrostrocaudal polarity

More Related Videos

Author Spotlight: Using Zebrafish to Explore Microglia Migration During Brain Development
07:45

Author Spotlight: Using Zebrafish to Explore Microglia Migration During Brain Development

Published on: May 17, 2024

2.2K
In Ovo and Ex Ovo Methods to Study Avian Inner Ear Development
10:09

In Ovo and Ex Ovo Methods to Study Avian Inner Ear Development

Published on: June 16, 2022

3.1K

Related Experiment Videos

Last Updated: Apr 16, 2026

Visualization of Tangential Cell Migration in the Developing Chick Optic Tectum
08:28

Visualization of Tangential Cell Migration in the Developing Chick Optic Tectum

Published on: October 24, 2018

7.0K
Author Spotlight: Using Zebrafish to Explore Microglia Migration During Brain Development
07:45

Author Spotlight: Using Zebrafish to Explore Microglia Migration During Brain Development

Published on: May 17, 2024

2.2K
In Ovo and Ex Ovo Methods to Study Avian Inner Ear Development
10:09

In Ovo and Ex Ovo Methods to Study Avian Inner Ear Development

Published on: June 16, 2022

3.1K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • The optic tectum serves as a primary visual processing center in nonmammalian vertebrates.
  • It develops from the mesencephalon, a key region of the developing brain.

Purpose of the Study:

  • This review examines the multifaceted roles of Engrailed (En) in the developmental processes of the optic tectum.
  • To elucidate how Engrailed influences regionalization, polarity, and cellular organization within the developing tectum.

Main Methods:

  • This review synthesizes existing research on Engrailed gene expression and function.
  • Analysis of studies focusing on gene expression patterns and their correlation with developmental events in the optic tectum.

Main Results:

  • Engrailed is crucial for the initial regionalization of the mesencephalon.
  • Engrailed establishes rostrocaudal polarity through a caudal-to-rostral gradient in the developing tectum.
  • Engrailed's lamina-specific expression suggests a role in regulating cell migration during tectal layer formation.

Conclusions:

  • Engrailed is a key regulator at multiple stages of optic tectum development.
  • Understanding Engrailed's function provides insights into the formation of visual processing centers.
  • Further research can explore therapeutic targets for developmental disorders affecting the brain.