Signaling Pathway that Controls Plant Cytokinesis

Cytokinesis is the final process of cell division cycle that properly separates cytoplasmic components and duplicated nuclei into two daughter cells. Plant cytokinesis occurs in phragmoplast, the cytokinetic machinery composed mainly of microtubule (MT) arrays. Recent studies have revealed that a plant-specific mitogen-activated protein kinase (MAPK) cascade is involved in cytokinesis. The activity of this cascade is controlled by cytokinesis-specific kinesin called NACK in tobacco and Arabidopsis, which is required for the cell plate formation in the phragmoplast. Functions of NACK are strictly controlled by cyclin-dependent kinase/cyclin B complexes so as to be activated at the correct timing for cytokinesis. Thus, this pathway constitutes a part of the regulatory system controlling the cell cycle progression. Here, we review recent advancements for understanding how the activation of this pathway can be specified in the late stage of the M phase and how this MAPK cascade can control cytokinesis through MT turnover.