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Advances in drug delivery to the posterior segment
William Pearce1, Jason Hsu, Steven Yeh
1aEmory Eye Center, Emory University School of Medicine, Atlanta, Georgia bRetina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, Pennsylvania, USA.
Current Opinion in Ophthalmology
|March 12, 2015
Summary
New drug delivery methods for posterior segment diseases, including implantable devices and targeted delivery, show promise for treating vitreoretinal conditions. These innovations aim to improve efficacy and reduce patient treatment burdens.
Area of Science:
- Ophthalmology
- Drug Delivery Systems
- Biomedical Engineering
Background:
- Vitreoretinal diseases require effective drug delivery to the posterior segment.
- Current treatments like intravitreal injections have limitations.
Purpose of the Study:
- To review emerging drug delivery technologies for posterior segment diseases.
- To inform clinicians about new indications and clinical trials.
Main Methods:
- Summary of advantages and disadvantages of common drug delivery methods.
- Discussion of vitreous dynamics, physician sustainability, and patient preferences.
Main Results:
- Intravitreal corticosteroid-release devices are available for retinal vascular disease and posterior uveitis.
- Suprachoroidal space offers a novel route for targeted drug delivery.
- Implantable reservoirs and encapsulated cell technology show promise for reduced injection frequency and improved outcomes.
Conclusions:
- Pars plana intravitreal injection is standard, but new methods are emerging.
- Targeted delivery and implantable devices demonstrate safety and efficacy.
- These advancements offer promising therapeutic options for vitreoretinal diseases.
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