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Spectral-domain Optical Coherence Tomography Patterns in Intraocular Lymphoma
Hiroshi Keino1, Annabelle A Okada1, Takayo Watanabe1
1a Department of Ophthalmology , Kyorin University School of Medicine , Tokyo , Japan .
Ocular Immunology and Inflammation
|March 12, 2015
Summary
Spectral-domain optical coherence tomography (SD-OCT) reveals outer retinal hyperreflective nodules and ellipsoid zone disruption in intraocular lymphoma (IOL). These SD-OCT patterns aid in early detection and treatment monitoring for IOL.
Area of Science:
- Ophthalmology
- Medical Imaging
- Oncology
Background:
- Intraocular lymphoma (IOL) is a rare malignancy affecting the eye.
- Accurate diagnosis and monitoring of IOL are crucial for effective treatment.
Observation:
- Spectral-domain optical coherence tomography (SD-OCT) was used to evaluate 21 eyes of 13 patients with IOL.
- SD-OCT imaging was performed at initial diagnosis and during follow-up visits.
Findings:
- Initial SD-OCT showed ellipsoid zone disruption (38.1%) and retinal pigment epithelium (RPE) hyperreflective nodules (23.8%).
- Follow-up SD-OCT revealed persistent ellipsoid zone disruption (47.6%) and RPE hyperreflective nodules (33.3%).
- Treatment with intravitreal methotrexate led to a reduction in RPE hyperreflective nodules in 5 eyes.
Implications:
- SD-OCT can identify characteristic patterns in IOL, including outer retinal nodules and ellipsoid zone disruption.
- These findings suggest SD-OCT's utility in the early detection of macular abnormalities in IOL.
- SD-OCT may serve as a valuable tool for monitoring treatment response in patients with IOL.
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