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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

Types of RNA

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

Types of RNA

Types of RNA

Types of RNA

Types of RNA

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Related Experiment Video

Updated: Apr 16, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Long noncoding RNA turnover.

Je-Hyun Yoon¹, Jiyoung Kim¹, Myriam Gorospe¹

¹Laboratory of Genetics, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.

|March 15, 2015

Summary

This summary is machine-generated.

This review explores how long noncoding RNAs (lncRNAs) are regulated. It summarizes key factors and mechanisms that control the stability of these crucial molecules in mammalian cells.

Keywords:

Long noncoding RNA RNA-binding protein Ribonucleoprotein complex

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Area of Science:

Molecular Biology
Genetics
Gene Regulation

Background:

Most RNAs in mammalian cells do not code for proteins, including a large group called long noncoding RNAs (lncRNAs).
lncRNAs play significant roles in regulating gene expression at various levels, including transcription, mRNA processing, and protein localization.
Understanding lncRNA regulation is crucial due to their broad impact on cellular functions.

Purpose of the Study:

To review and synthesize current knowledge on the factors and mechanisms controlling mammalian lncRNA stability.
To provide a comprehensive overview of how lncRNA levels are maintained in cells.

Main Methods:

Literature review and synthesis of existing research on lncRNA stability.
Analysis of various regulatory mechanisms impacting lncRNA levels.

Main Results:

lncRNA stability is influenced by a complex interplay of factors.
Mechanisms include transcriptional control, post-transcriptional modifications, and interactions with other molecules.
Cellular localization and protein binding also affect lncRNA turnover.

Conclusions:

lncRNA stability is a critical determinant of their regulatory functions.
Further research into these mechanisms will enhance our understanding of gene regulation.
Elucidating lncRNA stability pathways offers potential for therapeutic interventions.