Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Structure and function of P-glycoprotein.

Cancer Treatment and Research

|January 1, 1989

Summary

This summary is machine-generated.

P-glycoprotein is key to multidrug resistance, but understanding this transporter protein is still developing. Further research into P-glycoprotein will advance cancer drug resistance knowledge and fundamental transport system insights.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multidrug resistance proteins MRP3, MRP1, and MRP2 in lung cancer: correlation of protein levels with drug response and messenger RNA levels.

Clinical cancer research : an official journal of the American Association for Cancer Research·2001

Same author

Simultaneous quantitation of topoisomerase II alpha and beta isoform mRNAs in lung tumor cells and normal and malignant lung tissue.

Laboratory investigation; a journal of technical methods and pathology·2000

Same author

Sequence determinants of nuclear localization in the alpha and beta isoforms of human topoisomerase II.

Experimental cell research·1999

Same author

Expression of multidrug resistance protein-related genes in lung cancer: correlation with drug response.

Clinical cancer research : an official journal of the American Association for Cancer Research·1999

Same author

Structural organization of the human TOP2A and TOP2B genes.

Gene·1998

Same author

Multidrug resistance genes (MRP) and MDR1 expression in small cell lung cancer xenografts: relationship with response to chemotherapy.

Cancer letters·1998

Same journal

Clinical Trials and Translational Advances in Metabolic Targeting.

Cancer treatment and research·2026

Same journal

Tools and Technologies for Studying Cancer Metabolism.

Cancer treatment and research·2026

Same journal

Cancer and Immune Cells: A Metabolic Battle in the Tumor Microenvironment.

Cancer treatment and research·2026

Same journal

Biomarkers of Cancer Metabolism and Therapeutic Response.

Cancer treatment and research·2026

Same journal

Targeting Metabolism in Cancer Therapy: Inhibitors and Approaches.

Cancer treatment and research·2026

Same journal

Metabolic Reprogramming in Cancer Stem Cells.

Cancer treatment and research·2026

See all related articles

Area of Science:

Biochemistry
Molecular Biology
Pharmacology

Background:

P-glycoprotein is a well-characterized protein linked to multidrug resistance.
Despite extensive study, significant knowledge gaps regarding P-glycoprotein function persist.

Purpose of the Study:

To highlight the current state of understanding of P-glycoprotein.
To identify unanswered questions regarding P-glycoprotein's role in drug resistance and transport.

Main Methods:

Literature review and synthesis of existing research on P-glycoprotein.
Identification of key areas requiring further investigation.

Main Results:

P-glycoprotein is central to multidrug resistance.

Related Experiment Videos

Numerous questions regarding P-glycoprotein's mechanisms and implications remain unresolved.

Conclusions:

Continued research into P-glycoprotein is crucial for understanding cancer multidrug resistance.
Investigating P-glycoprotein will enhance knowledge of fundamental biological transport systems.