Related Experiment Video
Updated: Apr 16, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
A method to select aperture margin in collimated spot scanning proton therapy
Dongxu Wang1, Blake R Smith, Edgar Gelover
1Department of Radiation Oncology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.
This study introduces a method to determine the optimal aperture margin in proton therapy, enhancing dose gradients. The proposed framework ensures precise radiation delivery by calculating the maximum pencil beam center shift for improved treatment planning.
Area of Science:
- Medical Physics
- Radiation Oncology
- Particle Therapy
Background:
- Collimators and apertures sharpen lateral dose gradients in spot scanning proton therapy.
- A standardized method for determining aperture margins in proton therapy is currently lacking.
Purpose of the Study:
- To develop a theoretical framework for selecting optimal aperture margins in single-field collimated spot scanning proton therapy.
- To establish the spot spacing limit necessary for the existence of an optimal aperture margin.
Main Methods:
- Proposed an optimal margin equal to the maximum pencil beam center shift.
- Determined the required spot spacing limit based on beam modeling data.
- Validated the method with a test case.
Main Results:
- The theoretical framework provides a method for optimal aperture margin selection.
- A specific spot spacing limit was identified for the existence of the optimal margin.
- The test case demonstrated agreement with the proposed method's predictions.
Conclusions:
- The proposed method offers a way to determine optimal aperture margins in proton therapy.
- This approach can be implemented in commercial treatment planning systems for improved precision.
More Related Videos
07:57Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
Published on: March 24, 2022
10:25Single-Digit Nanometer Electron-Beam Lithography with an Aberration-Corrected Scanning Transmission Electron Microscope
Published on: September 14, 2018