Prophylactic antibiotics and prevention of surgical site infections

Healthcare-associated infections present a significant source of preventable morbidity and mortality. More than 30% of all healthcare-associated infections are represented by surgical site infections, making them the most common subtype. Studies suggest that 40% to 60% of these infections are preventable, yet many hospitals have yet to implement evidence-based best practices. This article reviews the impact of surgical site infections, describes their measurement and reporting, and most importantly provides perioperative strategies for their prevention with a focus on the appropriate use of prophylactic antibiotics.