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Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
Published on: September 19, 2018
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Signal transduction in cancer
Richard Sever1, Joan S Brugge2
1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.
Cold Spring Harbor Perspectives in Medicine
|April 3, 2015
Summary
Cancer arises from genetic and epigenetic changes that disrupt cell signaling pathways, leading to uncontrolled growth and spread. Understanding these alterations, like those in the PI3K-Akt and Ras-ERK pathways, is key to targeting cancer progression.
Area of Science:
- Oncology
- Molecular Biology
- Cell Biology
Background:
- Cancer development involves genetic and epigenetic alterations.
- These alterations disrupt normal cellular functions like proliferation, survival, and migration.
- Signaling pathways are frequently dysregulated in cancer progression.
Purpose of the Study:
- To explain how genetic and epigenetic alterations drive cancer.
- To illustrate the role of signaling pathways in cancer.
- To examine specific pathways like PI3K-Akt and Ras-ERK in cancer.
Main Methods:
- Analysis of genetic and epigenetic alterations in cancer cells.
- Examination of key signaling pathways involved in cancer.
- Focus on the PI3K-Akt and Ras-ERK signaling pathways.
Main Results:
- Genetic and epigenetic changes enable uncontrolled cell proliferation and survival.
- Dysregulated signaling pathways contribute to tumor microenvironment changes, angiogenesis, and inflammation.
- Mutations in proto-oncogenes and tumor suppressors lead to pathway hyperactivation or loss of regulation.
- The PI3K-Akt and Ras-ERK pathways exemplify signaling dysregulation in cancer.
Conclusions:
- Genetic and epigenetic alterations are fundamental drivers of cancer.
- Dysregulation of signaling pathways is a hallmark of cancer.
- Targeting these altered pathways offers therapeutic strategies for cancer treatment.
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