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Updated: Apr 15, 2026

Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts
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Bladder preservation strategies.

Ashesh B Jani1, Jason A Efstathiou2, William U Shipley2

  • 1Department of Radiation Oncology, Emory University, 1365 Clifton Road, Northeast, Suite A1300, Atlanta, GA 30322, USA.

Hematology/Oncology Clinics of North America
|April 4, 2015
PubMed
Summary
This summary is machine-generated.

Organ preservation for muscle-invasive bladder cancer using chemoradiotherapy offers a potentially curative alternative to cystectomy. This approach achieves 10-year survival rates comparable to cystectomy in selected patients.

Keywords:
Bladder cancerChemotherapyCystectomyOrgan preservationRadiotherapy

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Area of Science:

  • Oncology
  • Urology
  • Radiation Oncology

Background:

  • Cystectomy is the standard treatment for muscle-invasive bladder cancer in the US.
  • Organ preservation strategies are emerging as alternatives for select patients.

Purpose of the Study:

  • To evaluate the efficacy of organ preservation using concurrent chemotherapy and radiation after transurethral resection for muscle-invasive bladder cancer.

Main Methods:

  • Concurrent chemotherapy and radiotherapy following aggressive transurethral tumor resection.
  • Salvage cystectomy for invasive recurrence.
  • Analysis of published data from North America and Europe.

Main Results:

  • Achieved 10-year disease-specific survival rates of 60% to 65%.
  • Overall survival rates were similar to those observed with cystectomy in selected patients.

Conclusions:

  • Organ preservation with chemoradiotherapy is a viable, potentially curative option for select muscle-invasive bladder cancer patients.
  • Further research is ongoing to optimize chemoradiotherapy sequencing, timing, and fractionation.