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Atomic Force Microscopy

Atomic Force Microscopy

Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
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The cytoskeletal architecture can be studied using different microscopic and biochemical techniques. Electron microscopy was instrumental in discovering the cytoskeletal architecture around the 1960s, which allowed obtaining structural information at a high-resolution level. However, the sample preparation procedure often limits this ability in biological samples. Several protocols have been developed over the years to optimize sample preparation. In one of the protocols known as rotary...

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Related Experiment Video

Updated: Apr 15, 2026

Author Spotlight: Investigating Vascular Stiffness and Inflammation in Early Diabetic Retinopathy

Author Spotlight: Investigating Vascular Stiffness and Inflammation in Early Diabetic Retinopathy

Published on: July 12, 2024

Atomic force microscopy crosslinks interdisciplinary eye research

Christian M Hammer¹, Tilman E Schäffer²

¹Department of Anatomy II, Friedrich-Alexander-University, Erlangen, Germany ; Department of Ophthalmology, Friedrich-Alexander-University, Erlangen, Germany.

Medical Hypothesis, Discovery & Innovation Ophthalmology Journal

|April 11, 2015

Summary

No abstract available in PubMed .

Keywords:

Atomic Force Microscopy Eye Disease Interdisciplinary Eye Research

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