Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Teratogenicity01:07

Teratogenicity

4.6K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.6K
Fetal Circulation01:14

Fetal Circulation

4.9K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
4.9K
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

5.6K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chronic estrogen supplementation in the aging castrated male rat is not associated with renal injury or activation of the renin angiotensin system.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

Tumor necrosis factor alpha inhibition improves fetal growth in a rat model of preeclampsia.

Placenta·2026
Same author

Protective effects of fermentable dietary fiber and propionate in Dahl salt-sensitive hypertension and renal damage.

American journal of physiology. Renal physiology·2026
Same author

Effective mentoring in the academic biomedical sciences: a collaborative effort that takes a village.

Advances in physiology education·2025
Same author

Feminizing Hormone Therapy in the Male Spontaneous Hypertensive Rat Impairs Accuracy of Estimated Renal Filtration.

Journal of the Endocrine Society·2025
Same author

Exacerbation of Dahl SS Hypertension and Renal Damage by NOX2 in CD4+ T Cells.

Hypertension (Dallas, Tex. : 1979)·2025
Same journal

Heart-Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes.

Comprehensive Physiology·2026
Same journal

The Adipose-Organ Communication Network in Clinical Obesity: From Adiposopathy to Systemic Metabolic Failure.

Comprehensive Physiology·2026
Same journal

Insight Into the Biological Link Between Novel Adiposity Indices and Incident Heart Failure.

Comprehensive Physiology·2026
Same journal

Domino Effect of the Kynurenine Pathway: Systemic Homeostasis, Metabolic Crosstalk, and Therapeutic Potential.

Comprehensive Physiology·2026
Same journal

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases.

Comprehensive Physiology·2026
Same journal

Sleep Disturbances and Male Reproductive Dysfunction: Pathophysiological Mechanisms Linking Obstructive Sleep Apnea and Sleep Deprivation.

Comprehensive Physiology·2026
See all related articles

Related Experiment Video

Updated: Apr 14, 2026

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
14:40

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Published on: October 25, 2015

10.0K

Fetal programming and cardiovascular pathology.

Barbara T Alexander1, John Henry Dasinger, Suttira Intapad

  • 1Department of Physiology and Biophysics, Women's Health Research Center, Center for Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, Mississippi, USA.

Comprehensive Physiology
|April 17, 2015
PubMed
Summary
This summary is machine-generated.

Fetal growth impacts lifelong cardiovascular health. Impaired fetal growth, including low birth weight and macrosomia, increases the risk of developing high blood pressure and heart disease later in life.

More Related Videos

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System
07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

12.5K
Murine Fetal Echocardiography
08:04

Murine Fetal Echocardiography

Published on: February 15, 2013

18.3K

Related Experiment Videos

Last Updated: Apr 14, 2026

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
14:40

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Published on: October 25, 2015

10.0K
Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System
07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

12.5K
Murine Fetal Echocardiography
08:04

Murine Fetal Echocardiography

Published on: February 15, 2013

18.3K

Area of Science:

  • Developmental biology
  • Cardiovascular science
  • Public health

Background:

  • Low birth weight (LBW) and macrosomia are indicators of altered fetal growth.
  • LBW and macrosomia are linked to increased cardiovascular disease (CVD) risk.
  • Mechanisms underlying fetal programming of CVD are not fully understood.

Purpose of the Study:

  • To review how adverse fetal development influences cardiovascular pathology.
  • To explore mechanisms behind fetal origins of CVD.
  • To highlight the role of early life influences on adult cardiovascular health.

Main Methods:

  • Literature review of epidemiological and experimental studies.
  • Analysis of factors influencing fetal growth and their long-term health consequences.
  • Examination of physiological and epigenetic mechanisms.

Main Results:

  • Birth weight is inversely associated with blood pressure and coronary heart disease.
  • Maternal factors like obesity and diabetes contribute to macrosomia and CVD risk.
  • Epigenetic processes, sympathetic nervous system, renin-angiotensin system, oxidative stress, and endothelin are implicated in programming hypertension.

Conclusions:

  • Adverse influences during fetal life permanently alter an individual's cardiovascular health trajectory.
  • Early life growth patterns are critical determinants of adult cardiovascular risk.
  • Understanding these mechanisms is key to preventing intergenerational transmission of CVD risk.