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Updated: Apr 12, 2026
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Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
16.8K
The Return of Delayed-Type Hypersensitivity Skin Testing for Coccidioidomycosis
Elizabeth E Wack1, Neil M Ampel2, Rebecca H Sunenshine3
1Valley Fever Center for Excellence.
Summary
A skin test for coccidioidomycosis is available again. This review helps physicians understand its use in managing patients with past Coccidioides infection and as a research tool.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Immunology
Background:
- Coccidioidomycosis, a fungal infection, is endemic in certain regions.
- A diagnostic skin test for coccidioidomycosis was previously widely used but is now less familiar to clinicians.
- Physicians require updated information on the utility of coccidioidomycosis skin testing.
Purpose of the Study:
- To reintroduce the coccidioidomycosis skin test for clinical use.
- To educate healthcare providers on the application of skin testing in patient management.
- To provide a research tool for studying Coccidioides infection.
Main Methods:
- Review of historical clinical and epidemiological studies on coccidioidomycosis skin testing.
- Analysis of the composition of past and current skin test antigens.
- Comparison of preservatives in historical and contemporary skin test preparations.
Main Results:
- The coccidioidomycosis skin test is once again available for clinical application.
- Previous studies highlight the test's value in identifying past Coccidioides species infection.
- Differences in preservatives between old and new preparations are noted.
Conclusions:
- The coccidioidomycosis skin test can aid in diagnosing past infections.
- Understanding the test's historical use is crucial for current clinical practice.
- The updated skin test preparation offers a valuable tool for patient care and research.
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