Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

12.3K
Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
12.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Should reference beam data be used for beam modeling during linear accelerator commissioning?

Medical physics·2026
Same author

Effects of Bicarbonate Ions in Tea Brewing Water on Sensory Properties and Substances of Different Teas.

Foods (Basel, Switzerland)·2026
Same author

Protonated Defect-Engineered Carbon Nitride Enables Bio-Interface-Enhanced Photodynamic Antibacterial Activity with Potential Periodontal Application.

Materials (Basel, Switzerland)·2026
Same author

Monte Carlo modeling and phantom studies show Cherenkov emission per unit dose during total skin electron therapy is a function of tissue optical properties.

Medical physics·2026
Same author

3D Reactive Oxygen Species Dosimetry in Pleural Photodynamic Therapy: Integration of Macroscopic Kinetic Modeling and Deformable Registration.

Antioxidants (Basel, Switzerland)·2026
Same author

Impact of preoperative body weight on short-term and long-term prognosis after pancreatic resection for pancreatic ductal adenocarcinoma: a multicenter study.

Journal of gastrointestinal oncology·2026
Same journal

AVA: Automated Viewability Analysis for Ureteroscopic Intrarenal Surgery.

Proceedings of SPIE--the International Society for Optical Engineering·2026
Same journal

Kidney Endoscopy Video to Preoperative CT Alignment for Depth Estimation.

Proceedings of SPIE--the International Society for Optical Engineering·2026
Same journal

Deep learning‑based cell type prediction in lung tissue from brightfield histology using CODEX-derived labels.

Proceedings of SPIE--the International Society for Optical Engineering·2026
Same journal

Reconstructing physiological signals from fMRI across the adult lifespan.

Proceedings of SPIE--the International Society for Optical Engineering·2026
Same journal

Axially Swept Light-Sheet Microscopy using scattering and fluorescence contrast mechanisms.

Proceedings of SPIE--the International Society for Optical Engineering·2026
Same journal

Analytic Bounds on GAMLSS Model Variability of Normative White Matter Brain Charts.

Proceedings of SPIE--the International Society for Optical Engineering·2026
See all related articles

Related Experiment Video

Updated: Apr 12, 2026

Three-Dimensional Imaging of Tumor-Bearing Tissue Using the Iterative Bleaching Extends Multiplexity Approach
07:16

Three-Dimensional Imaging of Tumor-Bearing Tissue Using the Iterative Bleaching Extends Multiplexity Approach

Published on: April 25, 2025

925

Diffuse optical tomography using multichannel robotic platform for interstitial PDT.

Anna V Sharikova1, Xing Liang1, Timothy C Zhu1

  • 1Dept. of Radiation Oncology, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA USA 19104.

Proceedings of Spie--The International Society for Optical Engineering
|May 23, 2015
PubMed
Summary
This summary is machine-generated.

A new robotic platform speeds up data acquisition for Diffuse Optical Tomography (DOT) by optimizing scanning. This system accurately recovers optical properties (OP) in prostate phantoms, improving tumor imaging.

Keywords:
DOTPDTdiffuse optical tomographydosimetryphotodynamic therapyrobotic platform

More Related Videos

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
12:24

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

13.0K
Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
12:22

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Published on: August 4, 2018

9.1K

Related Experiment Videos

Last Updated: Apr 12, 2026

Three-Dimensional Imaging of Tumor-Bearing Tissue Using the Iterative Bleaching Extends Multiplexity Approach
07:16

Three-Dimensional Imaging of Tumor-Bearing Tissue Using the Iterative Bleaching Extends Multiplexity Approach

Published on: April 25, 2025

925
Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
12:24

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

13.0K
Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
12:22

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Published on: August 4, 2018

9.1K

Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Optical Physics

Background:

  • Operating room efficiency is critical, with data acquisition speed impacting measurement feasibility.
  • Accurate optical properties (OP) recovery is essential for effective Diffuse Optical Tomography (DOT).

Purpose of the Study:

  • To develop and validate a robotic platform for rapid and accurate DOT measurements.
  • To improve the precision of OP recovery in prostate phantom studies.

Main Methods:

  • A multichannel robotic platform with 16 independently moving fibers (0.05 mm resolution, 50 mm/s speed) was utilized.
  • Automated fiber alignment and peak/edge detection algorithms enabled simultaneous scanning.
  • Steady-state light diffusion equation and NIRFAST were employed for inverse problem solving and OP reconstruction.

Main Results:

  • The robotic platform achieved scanning times of approximately 10 seconds for complete DOT measurements.
  • Recovered OP values in homogenous and inhomogenous prostate phantoms agreed within 10% of actual values.
  • OP corrections significantly enhanced light fluence accuracy within the bulk tumor volume.

Conclusions:

  • The developed robotic platform substantially accelerates DOT data acquisition.
  • This technology enables precise optical property determination, crucial for accurate tumor characterization and treatment planning.