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Murine Model of Allergen Induced Asthma
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Specific Inhalation Challenge in Persulfate Asthma.

O Hagemeyer1, E Marek, V van Kampen

  • 1Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, D-44789, Bochum, Germany, hagemeyer@ipa-dguv.de.

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|May 30, 2015
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Summary
This summary is machine-generated.

A new six-step specific inhalation challenge (SIC) protocol for diagnosing occupational asthma from persulfate salts was developed and found to be safe. This method, along with patch testing, aids in identifying occupational asthma in hairdressers.

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Area of Science:

  • Occupational Medicine
  • Allergology
  • Pulmonology

Background:

  • Occupational asthma is a significant health concern, particularly in professions like hairdressing.
  • Persulfate salts, common in hair products, are known triggers for occupational asthma.
  • Specific inhalation challenge (SIC) is the gold standard for diagnosis but requires a safe protocol.

Purpose of the Study:

  • To develop and evaluate a safe specific inhalation challenge (SIC) protocol for diagnosing occupational asthma caused by persulfate salts.
  • To assess the diagnostic utility of skin prick tests and patch tests in conjunction with SIC.

Main Methods:

  • Eight hairdressers with suspected occupational asthma underwent SIC using ammonium persulfate via a dosimeter and nebulizer.
  • Two SIC protocols were used: a four-step (cumulative 0.5 mg) and a six-step (cumulative 0.6 mg) protocol.
  • Skin prick tests and patch tests were performed to evaluate their correlation with SIC results.

Main Results:

  • Four subjects (50%) showed a positive SIC, with two positive results from each protocol.
  • All positive SICs were associated with isolated late asthmatic reactions.
  • Patch testing showed a high positive rate (75%) in tested subjects, with three of four being SIC-positive.

Conclusions:

  • The proposed six-step SIC protocol appears safe for diagnosing occupational asthma due to persulfate salts.
  • Isolated late asthmatic reactions can occur following SIC.
  • Patch testing is recommended as an adjunct diagnostic tool for suspected occupational asthma from persulfate salts.