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Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons
Published on: August 23, 2016
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[Pregnancy and viral hepatitis B and C]
1Université Paris-Descartes, Sorbonne Paris Cité, France; AP-HP, hôpital Cochin, service d'hépatologie, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France.
Presse Medicale (Paris, France : 1983)
|June 3, 2015
Summary
Hepatitis B (HBV) and C (HCV) screening during pregnancy is mandatory in France. Serovaccination prevents transmission, but high maternal viral load may require antiviral treatment like tenofovir.
Area of Science:
- Hepatology
- Infectious Diseases
- Public Health
Context:
- Mandatory screening for Hepatitis B surface antigen (HBsAg) in pregnant women in France.
- Established protocol for neonatal serovaccination (anti-HBs immunoglobulins and vaccine) within 12 hours for HBsAg-positive mothers.
- Identified high maternal viral load (HBV-DNA > 7 log IU/mL) as a factor in serovaccination failure.
Purpose:
- To outline management strategies for preventing mother-to-child transmission of HBV and HCV.
- To address challenges in serovaccination efficacy related to maternal viral load.
- To inform clinical practice regarding delivery and breastfeeding in cases of maternal HBV/HCV infection.
Summary:
- Neonatal serovaccination is crucial for HBsAg-positive mothers, with failures linked to high HBV DNA levels.
- Antenatal treatment with tenofovir alongside serovaccination is recommended for high viral load cases.
- HCV transmission risk is 3-5% for HCV-RNA positive mothers without HIV co-infection. Delivery mode and breastfeeding are not contraindicated for HBV or HCV.
Impact:
- Ensures timely intervention to reduce HBV/HCV transmission rates.
- Provides evidence-based guidance for managing high-risk pregnancies.
- Supports safe delivery and infant feeding practices for infected mothers.
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