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Evaluation of (101)Rh as a brachytherapy source.

Delaram Pakravan1, Mahdi Ghorbani2, Ali Soleimani Meigooni3

  • 1Department of Physics, Faculty of Basic Sciences, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.

Journal of Contemporary Brachytherapy
|June 3, 2015
PubMed
Summary

Rhodium-101 (101Rh) is a promising alternative to current high-dose-rate (HDR) brachytherapy sources. Its favorable dosimetric properties and longer half-life offer potential clinical advantages.

Keywords:
101RhTG-43 dosimetric parametersbrachytherapyhypothetical source

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Nuclear Medicine

Background:

  • Brachytherapy utilizes radioactive sources for localized radiation treatment.
  • Existing high-dose-rate (HDR) sources have limitations that drive the search for alternatives.
  • Hypothetical sources are continuously evaluated to improve brachytherapy efficacy.

Purpose of the Study:

  • To evaluate a hypothetical Rhodium-101 (101Rh) source as a potential alternative to current HDR brachytherapy sources.
  • To determine the dosimetric characteristics of the (101)Rh source according to AAPM TG-43 recommendations.
  • To compare the dosimetric data of (101)Rh with existing (57)Co and (192)Ir sources.

Main Methods:

  • Simulations using the MCNPX Monte Carlo code were performed for the (101)Rh HDR source.
  • The geometric design was based on the Flexisource (192)Ir source.
  • Key dosimetric parameters, including air kerma strength, dose rate constant, radial dose function, and 2D anisotropy, were calculated.

Main Results:

  • The (101)Rh source exhibited an air kerma strength of 1.09 ± 0.01 U/mCi and a dose rate constant of 1.18 ± 0.08 cGy/(h.U).
  • The radial dose function for (101)Rh exceeded that of (192)Ir beyond 1.0 cm in phantom.
  • Two-dimensional anisotropy functions were found to be similar to the Flexisource (192)Ir.

Conclusions:

  • Rhodium-101 (101Rh) is proposed as a viable alternative for HDR brachytherapy.
  • The (101)Rh source offers medium energy photons, a longer half-life, and improved dose rate and radial dose functions compared to (192)Ir.
  • Its comparable anisotropy and extended half-life reduce the need for frequent source replacement in clinical settings.