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Valsartan
Febry Ardiana1, Suciati2, Gunawan Indrayanto2
1Research & Development, Bernofarm Pharmaceutical Company, Buduran-Sidoarjo, Indonesia.
Summary
Valsartan, an antihypertensive drug, is analyzed using various methods. Liquid chromatography-mass spectrometry (LC-MS) is recommended for complex samples like biological fluids.
Area of Science:
- Pharmacology
- Analytical Chemistry
- Materials Science
Background:
- Valsartan is a selective angiotensin receptor type II inhibitor used as an antihypertensive medication.
- It is commonly formulated as film-coated tablets.
- Understanding its properties and analytical methods is crucial for quality control and therapeutic monitoring.
Purpose of the Study:
- To review the analytical characterization of valsartan.
- To summarize methods for analyzing valsartan in pharmaceutical and biological samples.
- To provide recommendations for optimal analytical techniques.
Main Methods:
- Thermal analysis (e.g., DSC, TGA).
- Spectroscopic techniques (UV-Vis, IR, MS, NMR).
- Chromatographic methods (CE, TLC, HPLC, LC-MS).
Main Results:
- Detailed characterization of valsartan's thermal and spectroscopic properties.
- Identification and quantification of impurities and related compounds.
- Evaluation of various analytical methods for different matrices.
- Comparison of selected reaction monitoring (SRM) and selected ion monitoring (SIM) in LC-MS.
Conclusions:
- Valsartan exhibits distinct thermal and spectroscopic profiles.
- Multiple analytical techniques are available for its assessment.
- LC-MS, particularly using SRM, is the preferred method for analyzing valsartan in complex biological and herbal matrices.
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