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Updated: Apr 10, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
The Use of Spectral-Domain Optical Coherence Tomography to Detect Glaucoma Progression
Ricardo Y Abe1, Carolina P B Gracitelli2, Felipe A Medeiros3
1Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA ; Department of Ophthalmology, University of Campinas, Campinas, Brazil.
Abstract:
Detection of progression and measurement of rates of change is at the core of glaucoma management, and the use of Spectral Domain Optical Coherence Tomography (SD-OCT) has significantly improved our ability to evaluate change in the disease. In this review, we critically assess the existing literature on the use of SD-OCT for detecting glaucoma progression and estimating rates of change. We discuss aspects related to the reproducibility of measurements, their accuracy to detect longitudinal change over time, and the effect of aging on the ability to detect progression. In addition, we discuss recent studies evaluating the use of combined structure and function approaches to improve detection of glaucoma progression.
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