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Menopausal status does not predict Oncotype DX recurrence score.

Danielle N Carr1, Nora Vera1, Weihong Sun2

  • 1Morsani College of Medicine, University of South Florida, Tampa Florida.

The Journal of Surgical Research
|June 23, 2015
PubMed
Summary
This summary is machine-generated.

Menopausal status does not significantly impact the Recurrence Score (RS) for early-stage, ER-positive breast cancer. The Oncotype DX (ODX) assay is valuable regardless of menopausal status in these patients.

Keywords:
Adjuvant therapyBreast cancerOncotype DXPremenopausalRecurrence

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Area of Science:

  • Oncology
  • Genomics
  • Breast Cancer Research

Background:

  • Adjuvant treatment for early-stage, estrogen receptor (ER)-positive invasive breast cancer often relies on menopausal status.
  • The 21-gene assay Oncotype DX (ODX) predicts distant recurrence but is underutilized in premenopausal patients.
  • This study evaluates the relationship between menopausal status and ODX Recurrence Score (RS).

Purpose of the Study:

  • To investigate the association between menopausal status and the Recurrence Score (RS) in early-stage, ER-positive invasive breast cancer.
  • To determine if menopausal status influences the utility of the Oncotype DX (ODX) assay.
  • To inform clinical decision-making regarding ODX testing in premenopausal women.

Main Methods:

  • Retrospective review of 575 invasive breast cancer patients with known RS.
  • Classification of perimenopausal women as premenopausal for analysis.
  • Statistical comparison of menopausal status and RS using general linear regression and Wilcoxon rank-sum test.

Main Results:

  • Median RS was 16 for both premenopausal and postmenopausal women.
  • Menopausal status was not a significant predictor of RS (P=0.6780).
  • Premenopausal women had higher local-regional recurrence rates but similar distant recurrence and overall survival compared to postmenopausal women.

Conclusions:

  • Menopausal status has limited predictive value for distant recurrence in ER-positive, early-stage breast cancer.
  • The Oncotype DX (ODX) assay's predictive value is not significantly altered by menopausal status.
  • Clinicians should consider ODX testing for ER-positive, early-stage breast cancer irrespective of menopausal status.