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Changes of T-kininogen levels in plasma and liver during development of rats
I Hayashi1, A Kusunoki, Y Nagashima
1Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Advances in Experimental Medicine and Biology
|January 1, 1989
Abstract:
T-kininogen levels of plasma and liver were measured in rats during development by RIA. We found that higher levels of T-kininogen in plasma and liver of neonates and of the mother rats at around term. The plasma level of mature male rats was as low as 1/5 to 1/2 of that of mature female rats. T-kininogen levels in male and female rats increased after treatment with estradiol, indicating that sex hormones may regulate the physiological level of T-kininogen in rats.