Neurofollicular hamartoma: a light microscopic and immunohistochemical study

Neurofollicular hamartoma is an unusual, previously undescribed neoplasm characterized by a proliferation of spindle cells and hyperplastic pilosebaceous units. Five cases were reviewed. The lesions presented as single, asymptomatic, smooth, flesh-colored papules. Four were on the nose, and one on the adjacent nasolabial fold. Immunoperoxidase studies performed on two cases utilizing antibodies to S-100 antigen were positive in both. These lesions share some histological and clinical features with angiofibroma and neurofibroma.