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Hairy Cell Leukemia Presenting with Duodenal Involvement Duodenum: A Case Report
Parijat Sen1, Hamid Shaaban2, Tejas Modi2
1Department of Internal Medicine, Seton Hall University School of Health and Medical Sciences, St Michaels Medical Center, Newark, New Jersey, USA.
North American Journal of Medical Sciences
|July 23, 2015
Summary
This case report details a rare instance of adult hairy cell leukemia (HCL) involving the duodenum. The patient achieved remission with 2-chlorodeoxyadenosine (CDA) chemotherapy, highlighting its efficacy.
Area of Science:
- Hematology
- Gastroenterology
- Oncology
Background:
- Hairy cell leukemia (HCL) is a rare chronic lymphoid leukemia.
- Duodenal involvement in HCL is exceptionally uncommon in adults.
Observation:
- A 48-year-old male with a history of HCL presented with abdominal pain post-chemotherapy.
- Esophagogastroduodenoscopy revealed duodenal inflammation with atypical lymphocytes and plasma cells, confirming HCL involvement.
- Bone marrow biopsy showed residual disease initially, but resolved with treatment.
Findings:
- The patient received 2-chlorodeoxyadenosine (CDA) chemotherapy for HCL.
- Successful treatment resulted in the resolution of duodenal thickening and spleen size.
- The patient achieved clinical remission for six years, indicating long-term efficacy of CDA.
Implications:
- This case highlights the first reported instance of successful CDA treatment for duodenal HCL.
- It underscores the importance of thorough gastrointestinal workup in HCL patients with abdominal symptoms.
- CDA chemotherapy is a viable option for managing rare extra-nodal HCL manifestations.
