Keratoconus Clinical Findings According to Different Classifications

Area of Science:

• Ophthalmology
• Corneal Diseases
• Vision Science

Background:

• Keratoconus (KC) is a progressive corneal ectasia.
• Understanding demographic and topographic variations is crucial for KC management.
• Existing classifications may not fully capture disease heterogeneity.

Purpose of the Study:

• To analyze topographic and keratometric findings in keratoconus (KC) patients.
• To investigate variations based on age, sex, and KC severity.
• To identify key parameters for assessing KC progression.

Main Methods:

• Prospective cross-sectional study of 2073 eyes from 1081 KC patients.
• Ophthalmic examination and Pentacam measurements were performed.
• Patients were stratified by age, sex, and Amsler-Krumeich/KC severity classifications.

Main Results:

• Female KC patients were younger with higher keratometric (K) values and shallower anterior chambers.
• Thinnest corneal thickness was the most sensitive and specific parameter for KC severity.
• Amsler-Krumeich classification showed the highest correlation with other severity measures.

Conclusions:

• Demographic and topographic differences in KC are significant.
• Thinnest corneal thickness is a vital biomarker for KC staging.
• Findings enhance understanding for improved KC diagnosis and treatment strategies.