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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Eosinophilia in Dermatologic Disorders.

Elisabeth de Graauw1, Helmut Beltraminelli2, Hans-Uwe Simon3

  • 1Department of Dermatology, Inselspital, Freiburgstrasse, Bern CH-3010, Switzerland; Institute of Pharmacology, University of Bern, Inselspital, Bern CH-3010, Switzerland.

Immunology and Allergy Clinics of North America
|July 27, 2015
PubMed
Summary
This summary is machine-generated.

Eosinophils are linked to various skin conditions, including allergic, autoimmune, and neoplastic diseases. This review details their clinical patterns, histology, and pathogenesis for better diagnosis and treatment.

Keywords:
Atopic dermatitisCutaneous lymphomaDrug hypersensitivity reactionEosinophilic dermatitisEosinophilsHypereosinophilic syndromes

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Area of Science:

  • Dermatology
  • Immunology
  • Pathology

Background:

  • Eosinophil infiltration is a hallmark of diverse skin disorders.
  • These include allergic/immunologic, autoimmune, infectious, and neoplastic conditions.
  • Clinical manifestations range from eczematous to bullous lesions, often with pruritus.

Purpose of the Study:

  • To review eosinophilic skin diseases based on clinical patterns.
  • To correlate clinical findings with histologic features and diagnostic procedures.
  • To discuss the role of eosinophils in dermatologic disease pathogenesis.

Main Methods:

  • Literature review of eosinophilic skin diseases.
  • Analysis of clinical presentations, histologic findings, and diagnostic methods.
  • Discussion of current pathogenetic insights and therapeutic strategies.

Main Results:

  • Eosinophilic skin diseases present with varied clinical patterns.
  • Histologic examination and diagnostic procedures aid in classification.
  • Eosinophils play a significant role in the pathogenesis of these disorders.

Conclusions:

  • Understanding eosinophil roles is crucial for diagnosing and managing skin diseases.
  • Pathogenesis-based approaches guide current diagnostic and therapeutic strategies.
  • This review provides a framework for recognizing and treating eosinophilic dermatoses.