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Updated: Apr 6, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

Conclusions and Future Directions.

Jen-Chywan Wang¹, Charles Harris

¹Department of Nutritional Sciences and Toxicology, University of California Berkeley, 119 Morgan Hall, Berkeley, CA, USA, walwang@berkeley.edu.

Advances in Experimental Medicine and Biology

|July 29, 2015

Summary

This summary is machine-generated.

This book introduces glucocorticoid action, detailing hormone discovery, therapeutic uses, and receptor identification. It explores structural biology and highlights unanswered questions regarding varied cellular responses.

Related Experiment Videos

Last Updated: Apr 6, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

Area of Science:

Endocrinology
Molecular Biology
Structural Biology

Background:

Glucocorticoids are vital hormones with significant therapeutic applications, particularly in treating inflammatory diseases.
The historical progression includes hormone discovery, receptor identification, and the cloning of the glucocorticoid receptor.
Understanding glucocorticoid action is crucial for various medical and biological fields.

Purpose of the Study:

To provide a comprehensive introduction to glucocorticoid action.
To trace the historical discoveries and advancements in understanding glucocorticoid receptors.
To elucidate the molecular mechanisms and structural basis of glucocorticoid activity.

Main Methods:

Historical review of scientific literature and discoveries.
Biochemical techniques for receptor identification.
Molecular biology methods including gene cloning.
Structural biology approaches such as X-ray crystallography and nuclear magnetic resonance (NMR).

Main Results:

Detailed historical account from hormone discovery to receptor cloning.
Identification of the primary amino acid sequence of the glucocorticoid receptor.
Elucidation of receptor structure through X-ray crystallography and NMR.
Recognition of diverse glucocorticoid actions across different cell types.

Conclusions:

Glucocorticoid action is a complex process with a rich history of discovery.
Structural insights into the glucocorticoid receptor have advanced understanding of its function.
Varied transcriptional responses to glucocorticoids across cell types remain an area for future research, potentially involving epigenetic modifications.