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HgsDb: Haplogroups Database to understand migration and molecular risk assessment
Devender Arora1, Ajeet Singh1, Vikrant Sharma1
1Department of Biotechnology, G.B. Pant Engineering College, Pauri Garhwal, Uttarakhand, India.
Bioinformation
|August 1, 2015
Summary
HgsDb is a new database organizing human migration and adaptation data. It provides insights into 76 major mtDNA and Y-DNA haplogroups for molecular risk assessment and personalized medicine.
Area of Science:
- Human population genetics
- Molecular anthropology
- Bioinformatics
Background:
- Human migration across the globe has led to adaptations visible in physical traits.
- These adaptations are linked to distinct racial origins and haplogroup variations.
- Previous data on human migration and genetic markers were fragmented.
Purpose of the Study:
- To develop a centralized database (HgsDb) for human migration and molecular risk assessment.
- To consolidate information on major mitochondrial DNA (mt-DNA) and Y-DNA haplogroups.
- To support research in genealogy, medical biology, and personalized medicine.
Main Methods:
- Data compilation from open-source platforms like NCBI.
- Organization of information on 76 major mt-DNA and Y-DNA haplogroups and their subclasses.
- Inclusion of structural information for each haplogroup.
Main Results:
- HgsDb offers a comprehensive overview of major human haplogroups.
- The database links haplogroup structures to factors influencing migration and molecular risk.
- Provides detailed insights into maternal and paternal lineage patterns for genealogists.
Conclusions:
- HgsDb facilitates easier access to crucial data on human genetic diversity and migration.
- The database serves as a valuable resource for understanding human origins and adaptations.
- Supports advancements in personalized medicine through detailed genetic information.
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