Related Experiment Video

Updated: Apr 6, 2026

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
09:04

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

Published on: June 8, 2017

7.0K

Cerebral Malaria Complicated by Blindness, Deafness and Extrapyramidal Tract Manifestation

P C Manyike1, C Okike2, N B Onyire1

  • 1Department of Pediatrics, Federal Teaching Hospital, Abakaliki, Ebonyi, Nigeria.

Annals of Medical and Health Sciences Research
|August 1, 2015
PubMed

Insights

Cerebral malaria, a severe Plasmodium falciparum infection, can cause lasting disabilities like blindness and deafness. Prompt diagnosis and treatment are crucial to prevent these rare but devastating neurological complications.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Parasitology

Background:

  • Cerebral malaria is a severe complication of Plasmodium falciparum infection.
  • Neurological sequelae, including sensory and motor deficits, can be permanent and disabling.

Purpose of the Study:

  • To highlight rare neurological complications of cerebral malaria.
  • To emphasize the importance of early diagnosis and prompt treatment in endemic areas.

Main Methods:

  • Case presentation of an 8-year-old boy with severe cerebral malaria.
  • Treatment with intravenous quinine followed by chlorpromazine for extrapyramidal signs.

Main Results:

  • The patient experienced blindness, sensory-neural deafness, and extrapyramidal signs after regaining consciousness.
  • Extrapyramidal signs resolved with chlorpromazine; partial recovery of sight and hearing occurred before discharge.

Conclusions:

  • Cerebral malaria can lead to severe, though sometimes partially reversible, neurological deficits.
  • Vigilance for rare complications and timely intervention are essential for clinicians in malaria-endemic regions.
Keywords:
BlindnessCerebral malariaComa

More Related Videos

Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice12:48

Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice

Published on: January 2, 2013

13.3K
A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting07:27

A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting

Published on: May 16, 2013

19.2K

Related Concept Videos

Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
30
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
115
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.4K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
2.5K
Brainstem01:19

Brainstem

The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
8.2K